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Skeletal muscle-specific expression of PGC-1-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake

[7] The protein encoded by this gene protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell death and increases resistance to toxic challenges, especially oxidative stress

En modelos animales, esa seal se asocia con formacin de nuevos vasos sanguneos y con mejores marcadores de reparacin en tejidos con irrigacin limitada como tendones y ligamentos